@article{9472e157e52c4b23b6fe31ab211d87bb,
title = "Overview of the findings and advances in the neurocognitive and psychosocial functioning of mild to moderate pediatric CKD: perspectives from the Chronic Kidney Disease in Children (CKiD) cohort study",
abstract = "The Chronic Kidney Disease in Children (CKiD) prospective cohort study was designed to address the neurocognitive, growth, cardiovascular, and disease progression of children and adolescents with mild to moderate CKD. The study has had continuous funding from NIDDK for 17 years and has contributed significant advances in pediatric CKD. The goals of this educational review are threefold: (1) to provide an overview of the neurocognitive and psychosocial studies from CKiD to date; (2) to provide best practice recommendations for those working with the neurocognitive and psychosocial aspects of pediatric CKD based on CKiD findings; and (3) to help chart future goals and directives for both research and clinical practice. This collection of 22 empirical studies has produced a number of key findings for children and adolescents with mild to moderate CKD. While various studies suggest a relatively positive presentation for this population as a whole, without evidence of significant impairment or deterioration, findings do indicate the presence of neurocognitive dysfunction, emotional-behavioral difficulties, and lower quality of life for many children with CKD. These findings support the promotion of best practices that are accompanied by additional future clinical and research initiatives with this patient population.",
keywords = "CKiD study, Emotional-behavioral, Neurocognition, Pediatric CKD, Quality of life",
author = "Hooper, {Stephen R.} and Johnson, {Rebecca J.} and Gerson, {Arlene C.} and Lande, {Marc B.} and Shlomo Shinnar and Harshman, {Lyndsay A.} and Kogon, {Amy J.} and Matthew Matheson and Sharon Bartosh and Joann Carlson and Warady, {Bradley A.} and Furth, {Susan L.}",
note = "Funding Information: Data in this manuscript were collected by the Chronic Kidney Disease in Children (CKiD) prospective cohort study with clinical coordinating centers (Principal Investigators) at Children{\textquoteright}s Mercy Hospital and the University of Missouri—Kansas City (Bradley Warady, MD) and Children{\textquoteright}s Hospital of Philadelphia (Susan Furth, MD, PhD), Central Biochemistry Laboratory (George Schwartz, MD) at the University of Rochester Medical Center, and data coordinating center (Alvaro Mu{\~n}oz, PhD and Derek Ng, PhD) at the Johns Hopkins Bloomberg School of Public Health. The CKiD study is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (U01 DK066143, U01 DK066174, U24 DK082194, U24 DK066116). The CKiD website is located at https://statepi.jhsph.edu/ckid , and a list of CKiD collaborators can be found at https://statepi.jhsph.edu/ckid/site-investigators/ . Investigators can access the publication acknowledgment on the Investigator Resources page on the CKiD website: https://statepi.jhsph.edu/ckid/investigator-resources/ . The acknowledgment is also included in the concept sheet submission form and Publication Policy. Both documents have been updated with the new publication acknowledgement and have been reposted on the Investigator Resources page. Funding Information: Data in this manuscript were collected by the Chronic Kidney Disease in Children (CKiD) prospective cohort study with clinical coordinating centers (Principal Investigators) at Children?s Mercy Hospital and the University of Missouri?Kansas City (Bradley Warady, MD) and Children?s Hospital of Philadelphia (Susan Furth, MD, PhD), Central Biochemistry Laboratory (George Schwartz, MD) at the University of Rochester Medical Center, and data coordinating center (Alvaro Mu?oz, PhD and Derek Ng, PhD) at the Johns Hopkins Bloomberg School of Public Health. The CKiD study is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (U01 DK066143, U01 DK066174, U24 DK082194, U24 DK066116). The CKiD website is located at https://statepi.jhsph.edu/ckid , and a list of CKiD collaborators can be found at https://statepi.jhsph.edu/ckid/site-investigators/. Investigators can access the publication acknowledgment on the Investigator Resources page on the CKiD website: https://statepi.jhsph.edu/ckid/investigator-resources/. The acknowledgment is also included in the concept sheet submission form and Publication Policy. Both documents have been updated with the new publication acknowledgement and have been reposted on the Investigator Resources page. Data in this manuscript were collected by the Chronic Kidney Disease in Children (CKiD) prospective cohort study with clinical coordinating centers (Principal Investigators) at Children?s Mercy Hospital and the University of Missouri?Kansas City and Children?s Hospital of Philadelphia, Central Biochemistry Laboratory at the University of Rochester Medical Center, and data coordinating center at the Johns Hopkins Bloomberg School of Public Health. Additionally, data for approximately the first 13 years of this study are available in the form of a public use database. Funding Information: The CKiD study is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (U01-DK-66143, U01-DK-66174, U24-DK-082194, U24-DK-66116). Publisher Copyright: {\textcopyright} 2021, IPNA.",
year = "2022",
month = apr,
doi = "10.1007/s00467-021-05158-w",
language = "English (US)",
volume = "37",
pages = "765--775",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "4",
}