Ovulatory response to gonadotropin administration in maturing rats with lesions in the anterior hypothalamic area

J. P. Advis, C. Berbecken, E. O. Alvarez, S. Rodriguez

Research output: Contribution to journalArticlepeer-review

Abstract

The ovulatory response to PMS, HCG and estradiol valerate (E2V) was studied at different ages, in maturing rats lesioned in the anterior hypothalamic area (AHA). At 20 days of age, rats were lesioned by high frequency current in the AHA, while intact littermates were used as controls. AHA lesions result in advancement of puberty as previously reported (Advis and Ramirez, 1977). Sixteen hours after a single sc injection of 10 IU of HCG, 86 percent of the lesioned and none (0 percent) of the control animals ovulated at 25 days of age. At the same time, 72 hours after a single injection of 10 IU of PMS, control animals did not ovulate, while 7 percent of the lesioned animals did. The ovulatory response was similar between lesioned and intact rats when challenged with 30 IU of PMS or with combinations of PMS + HCG. Only lesioned animals (33 percent) ovulate at 25 days of age, 66 h after a single dose of estradiol (0.05 μg/rat). The results indicate that AHA lesions that induced precocious puberty are associated with an increase in ovarian sensitivity to gonadotropin.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalBiology of reproduction
Volume17
Issue number3
DOIs
StatePublished - 1977
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Cell Biology

Fingerprint

Dive into the research topics of 'Ovulatory response to gonadotropin administration in maturing rats with lesions in the anterior hypothalamic area'. Together they form a unique fingerprint.

Cite this