Oxidation of ion channels in the aging nervous system

Rahul Patel, Federico Sesti

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Ion channels are integral membrane proteins that allow passive diffusion of ions across membranes. In neurons and in other excitable cells, the harmonious coordination between the numerous types of ion channels shape and propagate electrical signals. Increased accumulation of reactive oxidative species (ROS), and subsequent oxidation of proteins, including ion channels, is a hallmark feature of aging and may contribute to cell failure as a result. In this review we discuss the effects of ROS on three major types of ion channels of the central nervous system, namely the potassium (K+), calcium (Ca2+) and sodium (Na+) channels. We examine two general mechanisms through which ROS affect ion channels: via direct oxidation of specific residues and via indirect interference of pathways that regulate the channels. The overall status of the present studies indicates that the interaction of ion channels with ROS is multimodal and pervasive in the central nervous system and likely constitutes a general mechanism of aging susceptibility.

Original languageEnglish (US)
Pages (from-to)174-185
Number of pages12
JournalBrain research
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


  • Aging
  • Ion channel
  • LTP
  • Oxidative stress

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