Oxidative conversion of N-dimethylformamidine nucleosides to N-cyano nucleosides

Bashar Mullah, Alex Andrus, Hong Zhao, Roger A. Jones

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Reaction of the N-dimethylformamidine (dmf) derivatives of 2′-deoxyguanosine, guanosine, and 2′-deoxyadenosine with iodine and aqueous ammonia gives the corresponding N-cyano nucleosides. This reaction occurs in oligonucleotides under conditions where iodine is reatined on the solid support, or in the synthesis column, prior to cleavage with aqueous ammonia. This base modification can be eliminated with lower iodine concentration in the oxidation reagent.

Original languageEnglish (US)
Pages (from-to)4373-4376
Number of pages4
JournalTetrahedron Letters
Issue number25
StatePublished - Jun 19 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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