Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium

David Seiden, Paraluman Navidad, Harvey Weiss

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We studied the oxygen diffusion distance in the rabbit myocardium in untreated animals and in animals treated with thyroxine (T4) for 3 days and 16 days. The subepicardial and subendocardial regions were studied separately. Sixteen days of T4 treatment results in significant cardiac hypertrophy. After 16 days, the percentage of the myocardium occupied by myocytes decreases as the volume of extracellular matrix increases. After 3 days, the number of myocyte mitochondria per unit volume of myocardium increases without an increase in mitochondrial volume. After 16 days the volume density of the myocyte mitochondria increases. Oxygen diffusion distance was determined by measuring the distance between the myocardial capillaries and the cardiomyocyte mitochondria. The deposition of extracellular matrix results in an increase in the distance between the myocardial capillaries and the myocytes. The distribution of the mitochondria within the myocytes remains unchanged resulting in an increased distance between the capillaries and the mitochondria, hence, an increased oxygen diffusion distance. There is some evidence that the mitochondria most distant from the capillaries are the mitochondria in which division is most frequent with T4 stimulation. This may be related to the relative deprivation of oxygen of these mitochondria.

Original languageEnglish (US)
Pages (from-to)917-930
Number of pages14
JournalJournal of Molecular and Cellular Cardiology
Volume20
Issue number10
DOIs
StatePublished - Jan 1 1988

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Thyroxine
Myocardium
Mitochondria
Oxygen
Rabbits
Muscle Cells
Extracellular Matrix
Mitochondrial Size
Cardiomegaly
Cardiac Myocytes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "We studied the oxygen diffusion distance in the rabbit myocardium in untreated animals and in animals treated with thyroxine (T4) for 3 days and 16 days. The subepicardial and subendocardial regions were studied separately. Sixteen days of T4 treatment results in significant cardiac hypertrophy. After 16 days, the percentage of the myocardium occupied by myocytes decreases as the volume of extracellular matrix increases. After 3 days, the number of myocyte mitochondria per unit volume of myocardium increases without an increase in mitochondrial volume. After 16 days the volume density of the myocyte mitochondria increases. Oxygen diffusion distance was determined by measuring the distance between the myocardial capillaries and the cardiomyocyte mitochondria. The deposition of extracellular matrix results in an increase in the distance between the myocardial capillaries and the myocytes. The distribution of the mitochondria within the myocytes remains unchanged resulting in an increased distance between the capillaries and the mitochondria, hence, an increased oxygen diffusion distance. There is some evidence that the mitochondria most distant from the capillaries are the mitochondria in which division is most frequent with T4 stimulation. This may be related to the relative deprivation of oxygen of these mitochondria.",
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Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium. / Seiden, David; Navidad, Paraluman; Weiss, Harvey.

In: Journal of Molecular and Cellular Cardiology, Vol. 20, No. 10, 01.01.1988, p. 917-930.

Research output: Contribution to journalArticle

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