P -coumaric acid and ursolic acid from corni fructus attenuated β-amyloid25-35-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells

Jeong Hyun Yoon, Kumju Youn, Chi Tang Ho, Mukund V. Karwe, Woo Sik Jeong, Mira Jun

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Neuroinflammatory responses induced by amyloid-beta peptide (Aβ) are important causes in the pathogenesis of Alzheimers disease (AD). Blockade of Aβ has emerged as a possible therapeutic approach to control the onset of AD. This study investigated the neuroprotective effects and molecular mechanisms of p-coumaric acid (p-CA) and ursolic acid (UA) from Corni fructus against Aβ25-35-induced toxicity in PC12 cells. p-CA and UA significantly inhibited the expression of iNOS and COX-2 in Aβ 25-35-injured PC12 cells. Blockade of nuclear translocation of the p65 subunit of nuclear factor κB (NF-κB) and phosphorylation of IκB- was also observed after p-CA and UA treatment. For the upstream kinases, UA exclusively reduced ERK1/2, p-38, and JNK phosphorylation, but p-CA suppressed ERK1/2 and JNK phosphorylation. Both compounds comprehensively inhibited NF-κB activity, but possibly with different upstream pathways. The results provide new insight into the pharmacological modes of p-CA and UA and their potential therapeutic application to AD.

Original languageEnglish (US)
Pages (from-to)4911-4916
Number of pages6
JournalJournal of agricultural and food chemistry
Volume62
Issue number21
DOIs
StatePublished - May 28 2014

Fingerprint

Cornus officinalis
Cornus
Coumaric Acids
ursolic acid
PC12 Cells
coumaric acids
p-coumaric acid
Toxicity
Phosphorylation
toxicity
Alzheimer disease
phosphorylation
Alzheimer Disease
mitogen-activated protein kinase
cells
neuroprotective effect
therapeutics
Amyloid beta-Peptides
Neuroprotective Agents
prostaglandin synthase

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • Alzheimers disease
  • COX-2
  • Corni fructus
  • IκB
  • MAPKs
  • NFκB
  • amyloid β peptide
  • iNOS
  • p-coumaric acid
  • ursolic acid

Cite this

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title = "P -coumaric acid and ursolic acid from corni fructus attenuated β-amyloid25-35-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells",
abstract = "Neuroinflammatory responses induced by amyloid-beta peptide (Aβ) are important causes in the pathogenesis of Alzheimers disease (AD). Blockade of Aβ has emerged as a possible therapeutic approach to control the onset of AD. This study investigated the neuroprotective effects and molecular mechanisms of p-coumaric acid (p-CA) and ursolic acid (UA) from Corni fructus against Aβ25-35-induced toxicity in PC12 cells. p-CA and UA significantly inhibited the expression of iNOS and COX-2 in Aβ 25-35-injured PC12 cells. Blockade of nuclear translocation of the p65 subunit of nuclear factor κB (NF-κB) and phosphorylation of IκB- was also observed after p-CA and UA treatment. For the upstream kinases, UA exclusively reduced ERK1/2, p-38, and JNK phosphorylation, but p-CA suppressed ERK1/2 and JNK phosphorylation. Both compounds comprehensively inhibited NF-κB activity, but possibly with different upstream pathways. The results provide new insight into the pharmacological modes of p-CA and UA and their potential therapeutic application to AD.",
keywords = "Alzheimers disease, COX-2, Corni fructus, IκB, MAPKs, NFκB, amyloid β peptide, iNOS, p-coumaric acid, ursolic acid",
author = "Yoon, {Jeong Hyun} and Kumju Youn and Ho, {Chi Tang} and Karwe, {Mukund V.} and Jeong, {Woo Sik} and Mira Jun",
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P -coumaric acid and ursolic acid from corni fructus attenuated β-amyloid25-35-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells. / Yoon, Jeong Hyun; Youn, Kumju; Ho, Chi Tang; Karwe, Mukund V.; Jeong, Woo Sik; Jun, Mira.

In: Journal of agricultural and food chemistry, Vol. 62, No. 21, 28.05.2014, p. 4911-4916.

Research output: Contribution to journalArticle

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AU - Ho, Chi Tang

AU - Karwe, Mukund V.

AU - Jeong, Woo Sik

AU - Jun, Mira

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