P -coumaric acid and ursolic acid from corni fructus attenuated β-amyloid25-35-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells

Jeong Hyun Yoon, Kumju Youn, Chi Tang Ho, Mukund V. Karwe, Woo Sik Jeong, Mira Jun

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Neuroinflammatory responses induced by amyloid-beta peptide (Aβ) are important causes in the pathogenesis of Alzheimers disease (AD). Blockade of Aβ has emerged as a possible therapeutic approach to control the onset of AD. This study investigated the neuroprotective effects and molecular mechanisms of p-coumaric acid (p-CA) and ursolic acid (UA) from Corni fructus against Aβ25-35-induced toxicity in PC12 cells. p-CA and UA significantly inhibited the expression of iNOS and COX-2 in Aβ 25-35-injured PC12 cells. Blockade of nuclear translocation of the p65 subunit of nuclear factor κB (NF-κB) and phosphorylation of IκB- was also observed after p-CA and UA treatment. For the upstream kinases, UA exclusively reduced ERK1/2, p-38, and JNK phosphorylation, but p-CA suppressed ERK1/2 and JNK phosphorylation. Both compounds comprehensively inhibited NF-κB activity, but possibly with different upstream pathways. The results provide new insight into the pharmacological modes of p-CA and UA and their potential therapeutic application to AD.

Original languageEnglish (US)
Pages (from-to)4911-4916
Number of pages6
JournalJournal of agricultural and food chemistry
Volume62
Issue number21
DOIs
StatePublished - May 28 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • Alzheimers disease
  • COX-2
  • Corni fructus
  • IκB
  • MAPKs
  • NFκB
  • amyloid β peptide
  • iNOS
  • p-coumaric acid
  • ursolic acid

Fingerprint Dive into the research topics of 'P -coumaric acid and ursolic acid from corni fructus attenuated β-amyloid<sub>25-35</sub>-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells'. Together they form a unique fingerprint.

Cite this