P50: A candidate ERP biomarker of prodromal Alzheimer's disease

Deborah L. Green, Lisa Payne, Robi Polikar, Paul J. Moberg, David A. Wolk, John Kounios

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Introduction Reductions of cerebrospinal fluid (CSF) amyloid-beta (Aβ42) and elevated phosphorylated-tau (p-Tau) reflect in vivo Alzheimer's disease (AD) pathology and show utility in predicting conversion from mild cognitive impairment (MCI) to dementia. We investigated the P50 event-related potential component as a noninvasive biomarker of AD pathology in non-demented elderly. Methods 36 MCI patients were stratified into amyloid positive (MCI-AD, n=17) and negative (MCI-Other, n=19) groups using CSF levels of Aβ42. All amyloid positive patients were also p-Tau positive. P50s were elicited with an auditory oddball paradigm. Results MCI-AD patients yielded larger P50s than MCI-Other. The best amyloid-status predictor model showed 94.7% sensitivity, 94.1% specificity and 94.4% total accuracy. Discussion P50 predicted amyloid status in MCI patients, thereby showing a relationship with AD pathology versus MCI from another etiology. The P50 may have clinical utility for inexpensive pre-screening and assessment of Alzheimer's pathology.

Original languageEnglish (US)
Pages (from-to)390-397
Number of pages8
JournalBrain research
Volume1624
DOIs
StatePublished - 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Alzheimer's disease (AD)
  • Amyloid-beta
  • Auditory oddball paradigm
  • Cerebrospinal fluid biomarkers
  • Event-related potential (ERP)
  • P50

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