Abstract
Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2319-2325 |
| Number of pages | 7 |
| Journal | Carcinogenesis |
| Volume | 18 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 1997 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
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p53-dependent response in UV-induced transformation. / Zhang, Weihua; Zhang, Xin; Zhu, Hua; Chen, Suzie.
In: Carcinogenesis, Vol. 18, No. 12, 01.12.1997, p. 2319-2325.Research output: Contribution to journal › Article
TY - JOUR
T1 - p53-dependent response in UV-induced transformation
AU - Zhang, Weihua
AU - Zhang, Xin
AU - Zhu, Hua
AU - Chen, Suzie
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.
AB - Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.
UR - http://www.scopus.com/inward/record.url?scp=0031410190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031410190&partnerID=8YFLogxK
U2 - 10.1093/carcin/18.12.2319
DO - 10.1093/carcin/18.12.2319
M3 - Article
C2 - 9450476
AN - SCOPUS:0031410190
VL - 18
SP - 2319
EP - 2325
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 12
ER -