p53-dependent response in UV-induced transformation

Weihua Zhang, Xin Zhang, Hua Zhu, Suzie Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.

Original languageEnglish (US)
Pages (from-to)2319-2325
Number of pages7
JournalCarcinogenesis
Volume18
Issue number12
DOIs
StatePublished - Dec 1 1997

Fingerprint

p53 Genes
Nucleic Acid Databases
Gene Frequency
Clone Cells
DNA
Growth
Serum
Proteins

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Zhang, Weihua ; Zhang, Xin ; Zhu, Hua ; Chen, Suzie. / p53-dependent response in UV-induced transformation. In: Carcinogenesis. 1997 ; Vol. 18, No. 12. pp. 2319-2325.
@article{e5efb43cb3424ce7998cff4995e230fc,
title = "p53-dependent response in UV-induced transformation",
abstract = "Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.",
author = "Weihua Zhang and Xin Zhang and Hua Zhu and Suzie Chen",
year = "1997",
month = "12",
day = "1",
doi = "10.1093/carcin/18.12.2319",
language = "English (US)",
volume = "18",
pages = "2319--2325",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "12",

}

p53-dependent response in UV-induced transformation. / Zhang, Weihua; Zhang, Xin; Zhu, Hua; Chen, Suzie.

In: Carcinogenesis, Vol. 18, No. 12, 01.12.1997, p. 2319-2325.

Research output: Contribution to journalArticle

TY - JOUR

T1 - p53-dependent response in UV-induced transformation

AU - Zhang, Weihua

AU - Zhang, Xin

AU - Zhu, Hua

AU - Chen, Suzie

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.

AB - Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.

UR - http://www.scopus.com/inward/record.url?scp=0031410190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031410190&partnerID=8YFLogxK

U2 - 10.1093/carcin/18.12.2319

DO - 10.1093/carcin/18.12.2319

M3 - Article

C2 - 9450476

AN - SCOPUS:0031410190

VL - 18

SP - 2319

EP - 2325

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 12

ER -