Abstract
Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.
Original language | English (US) |
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Pages (from-to) | 2319-2325 |
Number of pages | 7 |
Journal | Carcinogenesis |
Volume | 18 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1997 |
All Science Journal Classification (ASJC) codes
- Cancer Research