p53-dependent response in UV-induced transformation

Weihua Zhang, Xin Zhang, Hua Zhu, Suzie Chen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.

Original languageEnglish (US)
Pages (from-to)2319-2325
Number of pages7
JournalCarcinogenesis
Volume18
Issue number12
DOIs
StatePublished - Dec 1 1997

All Science Journal Classification (ASJC) codes

  • Cancer Research

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