p63 in corneal and epidermal differentiation

Flavia Novelli; Carlo Ganini; Gerry Melino; Carlo Nucci; Yuyi Han; Yufang Shi; Ying Wang; Eleonora Candi

doi:10.1016/j.bbrc.2022.04.022

p63 in corneal and epidermal differentiation

Flavia Novelli, Carlo Ganini, Gerry Melino, Carlo Nucci, Yuyi Han, Yufang Shi, Ying Wang, Eleonora Candi

Robert Wood Johnson Medical School (RWJMS), Child Health Institute of New Jersey (CHINJ)

Research output: Contribution to journal › Short survey › peer-review

16 Scopus citations

Abstract

The transcription factor p63, belonging to the p53 family, is considered the master regulator of epidermal differentiation, skin, and in general of the differentiation of ectodermal tissues. Mutations in TP63 gene cause several rare ectodermal dysplasia disorders that refers to epidermal structural abnormalities and ocular surface disease, such as Ectrodactyly Ectodermal Dysplasia Clefting (EEC) syndrome. In this review, we discuss the key roles of p63 in keratinocytes and corneal epithelial differentiation, highlighting the function of the ΔNp63α isoform in driving limbal stem cell and epithelial stem cells commitment. We have summarized the specific ocular phenotypes observed in the TP63-mutation derived EEC syndrome, discussing the current and novel therapeutic strategies for the management of the ocular manifestations in EEC syndrome.

Original language	English (US)
Pages (from-to)	15-22
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	610
DOIs	https://doi.org/10.1016/j.bbrc.2022.04.022
State	Published - Jun 25 2022

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Keywords

Ectodermal dysplasia
Epithelia
Eye
Keratinocytes
Limbal stem cell
Skin
p63

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10.1016/j.bbrc.2022.04.022

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title = "p63 in corneal and epidermal differentiation",

abstract = "The transcription factor p63, belonging to the p53 family, is considered the master regulator of epidermal differentiation, skin, and in general of the differentiation of ectodermal tissues. Mutations in TP63 gene cause several rare ectodermal dysplasia disorders that refers to epidermal structural abnormalities and ocular surface disease, such as Ectrodactyly Ectodermal Dysplasia Clefting (EEC) syndrome. In this review, we discuss the key roles of p63 in keratinocytes and corneal epithelial differentiation, highlighting the function of the ΔNp63α isoform in driving limbal stem cell and epithelial stem cells commitment. We have summarized the specific ocular phenotypes observed in the TP63-mutation derived EEC syndrome, discussing the current and novel therapeutic strategies for the management of the ocular manifestations in EEC syndrome.",

keywords = "Ectodermal dysplasia, Epithelia, Eye, Keratinocytes, Limbal stem cell, Skin, p63",

author = "Flavia Novelli and Carlo Ganini and Gerry Melino and Carlo Nucci and Yuyi Han and Yufang Shi and Ying Wang and Eleonora Candi",

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doi = "10.1016/j.bbrc.2022.04.022",

language = "English (US)",

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T1 - p63 in corneal and epidermal differentiation

AU - Novelli, Flavia

AU - Ganini, Carlo

AU - Melino, Gerry

AU - Nucci, Carlo

AU - Han, Yuyi

AU - Shi, Yufang

AU - Wang, Ying

AU - Candi, Eleonora

PY - 2022/6/25

Y1 - 2022/6/25

N2 - The transcription factor p63, belonging to the p53 family, is considered the master regulator of epidermal differentiation, skin, and in general of the differentiation of ectodermal tissues. Mutations in TP63 gene cause several rare ectodermal dysplasia disorders that refers to epidermal structural abnormalities and ocular surface disease, such as Ectrodactyly Ectodermal Dysplasia Clefting (EEC) syndrome. In this review, we discuss the key roles of p63 in keratinocytes and corneal epithelial differentiation, highlighting the function of the ΔNp63α isoform in driving limbal stem cell and epithelial stem cells commitment. We have summarized the specific ocular phenotypes observed in the TP63-mutation derived EEC syndrome, discussing the current and novel therapeutic strategies for the management of the ocular manifestations in EEC syndrome.

AB - The transcription factor p63, belonging to the p53 family, is considered the master regulator of epidermal differentiation, skin, and in general of the differentiation of ectodermal tissues. Mutations in TP63 gene cause several rare ectodermal dysplasia disorders that refers to epidermal structural abnormalities and ocular surface disease, such as Ectrodactyly Ectodermal Dysplasia Clefting (EEC) syndrome. In this review, we discuss the key roles of p63 in keratinocytes and corneal epithelial differentiation, highlighting the function of the ΔNp63α isoform in driving limbal stem cell and epithelial stem cells commitment. We have summarized the specific ocular phenotypes observed in the TP63-mutation derived EEC syndrome, discussing the current and novel therapeutic strategies for the management of the ocular manifestations in EEC syndrome.

KW - Ectodermal dysplasia

KW - Epithelia

KW - Eye

KW - Keratinocytes

KW - Limbal stem cell

KW - Skin

KW - p63

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U2 - 10.1016/j.bbrc.2022.04.022

DO - 10.1016/j.bbrc.2022.04.022

M3 - Short survey

C2 - 35430447

AN - SCOPUS:85128172985

SN - 0006-291X

VL - 610

SP - 15

EP - 22

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

ER -

p63 in corneal and epidermal differentiation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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