Pain sensitivity in silent myocardial ischemia

Murray Glusman, James Coromilas, W. Crawford Clark, Malvin N. Janal, David K. Blood, John P. Kuhl, Kathleen Burns

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Although the cause of silent myocardial ischemia (SMI) is unknown, several theories have been advanced to explain the disorder. Most prominent among these are the suggestions that attribute the condition to generalized impaired pain sensitivity and/or enhanced endorphin activity. The present stud) examined both hypotheses. It was carried out in 33 patients with myocardial ischemia: 13 with silent myocardial ischemia (silents) and 20 with symptomatic ischemia (symptomatics). Pain sensitivity was determined with thermal, electrical, and ischemic pain tests using signal detection theory (SDT) and conventional threshold procedures. To evaluate the significance of endorphin mechanisms naloxone (6 mg i.v.) and placebo were administered on alternate days in a double-blind, cross-over procedure before the pain tests and again before a treadmill exercise test (TET). Somatic pain sensitivity was found not to be impaired in patients with SMI, and no evidence was found to support a causal role for endorphins in the disorder.

Original languageEnglish (US)
Pages (from-to)477-483
Number of pages7
JournalPain
Volume64
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Fingerprint

Endorphins
Myocardial Ischemia
Pain
Exercise Test
Nociceptive Pain
Naloxone
Ischemia
Hot Temperature
Placebos

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Glusman, M., Coromilas, J., Clark, W. C., Janal, M. N., Blood, D. K., Kuhl, J. P., & Burns, K. (1996). Pain sensitivity in silent myocardial ischemia. Pain, 64(3), 477-483. https://doi.org/10.1016/0304-3959(95)00142-5
Glusman, Murray ; Coromilas, James ; Clark, W. Crawford ; Janal, Malvin N. ; Blood, David K. ; Kuhl, John P. ; Burns, Kathleen. / Pain sensitivity in silent myocardial ischemia. In: Pain. 1996 ; Vol. 64, No. 3. pp. 477-483.
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Glusman, M, Coromilas, J, Clark, WC, Janal, MN, Blood, DK, Kuhl, JP & Burns, K 1996, 'Pain sensitivity in silent myocardial ischemia', Pain, vol. 64, no. 3, pp. 477-483. https://doi.org/10.1016/0304-3959(95)00142-5

Pain sensitivity in silent myocardial ischemia. / Glusman, Murray; Coromilas, James; Clark, W. Crawford; Janal, Malvin N.; Blood, David K.; Kuhl, John P.; Burns, Kathleen.

In: Pain, Vol. 64, No. 3, 01.01.1996, p. 477-483.

Research output: Contribution to journalArticle

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Glusman M, Coromilas J, Clark WC, Janal MN, Blood DK, Kuhl JP et al. Pain sensitivity in silent myocardial ischemia. Pain. 1996 Jan 1;64(3):477-483. https://doi.org/10.1016/0304-3959(95)00142-5