Palmitoylation in the nucleus: A little fat around the edges

Catherine A. Fox, Marc R. Gartenberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Many proteins are post-translationally modified by lipid moieties such as palmitoyl or prenyl (e.g., farnesyl) groups, creating functional proteolipids. Lipid modifications share the property of increasing a protein's hydrophobicity and thus the propensity of that protein to associate with a membrane. These modifications are used to control the localization and activity of membrane-associated proteins. A well-recognized paradigm is farnesylation of the Ras GTPase that helps target this critical signaling protein to the plasma membrane.

Original languageEnglish (US)
JournalNucleus (United States)
Volume3
Issue number3
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Cell Biology

Keywords

  • Chromosomes
  • Rif1
  • SIRS
  • Silencing
  • Telomeres

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