@article{b5b1d48767eb48d5b24ead15f8183954,
title = "Paneth Cell Multipotency Induced by Notch Activation following Injury",
abstract = "Using a knockin allele engineered at the mouse Lyz1 locus, Yu et al. report that irradiation induces a subset of Paneth cells to dedifferentiate. This process can also be induced by expressing active Notch1 in this cell type. The study documents Paneth cell plasticity, expanding current understanding of intestinal regeneration.",
keywords = "Lyz1, Notch, Paneth cell, RNA-seq, Wnt, intestinal stem cell, lysozyme, plasticity",
author = "Shiyan Yu and Kevin Tong and Yanlin Zhao and Iyshwarya Balasubramanian and Yap, {George S.} and Ferraris, {Ronaldo P.} and Bonder, {Edward M.} and Verzi, {Michael P.} and Nan Gao",
note = "Funding Information: The authors are grateful to Drs. Alexis Rodriguez and Lanjing Zhang for helpful discussion of the project and investigators in the group of Dr. Linda C. Samuelson (University of Michigan) and Dr. Ken Lau (Vanderbilt University) for sharing immunohistochemistry protocols. We are indebted to Dr. Ghassan Yehia (Rutgers Genome Editing Core Facility); Drs. Sukhwinder Singh, Hong Liu, and Tammy Mui-Galenkamp (Rutgers-NJMS Flow Cytometry Core); Kay Long, Larry Barbour, and staff (Newark Animal Facility); and Luke Fritzky (Rutgers-NJMS Histology Core) for numerous instances of technical assistance and experimental coordination. This work was supported by the NIH (grants DK102934, DK093809, and CA178599), the NSF/BIO/IDBR (grant 1353890), the American Cancer Society (grant RSG-15-060-01-TBE), a Rutgers IMRT award (to N.G.), grant R01CA190558 (to M.P.V.), grant R01AI134040 (to G.S.Y.), the NSF (grant IOS-1456673 to R.P.F.), and two instruments grants (1S10ODO18103 and 1S10RR027022-01A1 to the Rutgers-NJMS Flow Cytometry and Immunology Core Laboratory). S.Y. is supported by a Crohn's & Colitis Foundation of America career development award (406794). Funding Information: The authors are grateful to Drs. Alexis Rodriguez and Lanjing Zhang for helpful discussion of the project and investigators in the group of Dr. Linda C. Samuelson (University of Michigan) and Dr. Ken Lau (Vanderbilt University) for sharing immunohistochemistry protocols. We are indebted to Dr. Ghassan Yehia (Rutgers Genome Editing Core Facility); Drs. Sukhwinder Singh, Hong Liu, and Tammy Mui-Galenkamp (Rutgers-NJMS Flow Cytometry Core); Kay Long, Larry Barbour, and staff (Newark Animal Facility); and Luke Fritzky (Rutgers-NJMS Histology Core) for numerous instances of technical assistance and experimental coordination. This work was supported by the NIH (grants DK102934 , DK093809 , and CA178599 ), the NSF/BIO/IDBR (grant 1353890 ), the American Cancer Society (grant RSG-15-060-01-TBE ), a Rutgers IMRT award (to N.G.), grant R01CA190558 (to M.P.V.), grant R01AI134040 (to G.S.Y.), the NSF (grant IOS-1456673 to R.P.F.), and two instruments grants ( 1S10ODO18103 and 1S10RR027022-01A1 to the Rutgers-NJMS Flow Cytometry and Immunology Core Laboratory). S.Y. is supported by a Crohn{\textquoteright}s & Colitis Foundation of America career development award ( 406794 ). ",
year = "2018",
month = jul,
day = "5",
doi = "10.1016/j.stem.2018.05.002",
language = "English (US)",
volume = "23",
pages = "46--59.e5",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "1",
}