Paneth Cell Multipotency Induced by Notch Activation following Injury

Shiyan Yu, Kevin Tong, Yanlin Zhao, Iyshwarya Balasubramanian, George S. Yap, Ronaldo P. Ferraris, Edward M. Bonder, Michael P. Verzi, Nan Gao

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Using a knockin allele engineered at the mouse Lyz1 locus, Yu et al. report that irradiation induces a subset of Paneth cells to dedifferentiate. This process can also be induced by expressing active Notch1 in this cell type. The study documents Paneth cell plasticity, expanding current understanding of intestinal regeneration.

Original languageEnglish (US)
Pages (from-to)46-59.e5
JournalCell Stem Cell
Issue number1
StatePublished - Jul 5 2018

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology


  • Lyz1
  • Notch
  • Paneth cell
  • RNA-seq
  • Wnt
  • intestinal stem cell
  • lysozyme
  • plasticity


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