Parkinson's disease

A review

Research output: Contribution to journalReview article

142 Citations (Scopus)

Abstract

Parkinson's Disease is the second most common progressive neurodegenerative disorder affecting older American adults and is predicted to increase in prevalence as the United States population ages. Resulting from a pathophysiologic loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the development of neuronal Lewy Bodies, idiopathic Parkinson's Disease is associated with risk factors including aging, family history, pesticide exposure and environmental chemicals (e.g., synthetic heroin use). Its ultimate cause(s) is (are) unknown. Characterized by both motor and non-motor symptoms, PD patients classically display rest tremor, rigidity, bradykinesia, and stooping posture. PD can also be associated with neurobehavioral disorders (depression, anxiety), cognitive impairment (dementia), and autonomic dysfunction (e.g., orthostasis and hyperhidrosis). Recent decades have witnessed a proliferation of medical pharmacologic therapies and innovative surgical interventions like deep brain stimulation (DBS). However, definitive disease-modifying therapy is still lacking. Experimental therapies are being developed and tested with limited results. Knowledge of strategies to promote optimal quality of life for PD patients is of paramount importance for caregivers, health providers and patients themselves.

Original languageEnglish (US)
Pages (from-to)65-74
Number of pages10
JournalFrontiers in Bioscience - Scholar
Volume6 S
Issue number1
StatePublished - Jan 1 2014

Fingerprint

Parkinson Disease
Investigational Therapies
Hyperhidrosis
Hypokinesia
Deep Brain Stimulation
Dopaminergic Neurons
Heroin
Environmental Exposure
Dizziness
Tremor
Substantia Nigra
Mesencephalon
Anxiety Disorders
Posture
Pesticides
Rigidity
Neurodegenerative Diseases
Caregivers
Neurons
Dementia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Keywords

  • Dopaminergic therapy
  • Motor symptoms
  • Nonmotor symptoms
  • Parkinson's disease
  • Surgical therapy

Cite this

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Parkinson's disease : A review. / Beitz, Janice.

In: Frontiers in Bioscience - Scholar, Vol. 6 S, No. 1, 01.01.2014, p. 65-74.

Research output: Contribution to journalReview article

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AB - Parkinson's Disease is the second most common progressive neurodegenerative disorder affecting older American adults and is predicted to increase in prevalence as the United States population ages. Resulting from a pathophysiologic loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the development of neuronal Lewy Bodies, idiopathic Parkinson's Disease is associated with risk factors including aging, family history, pesticide exposure and environmental chemicals (e.g., synthetic heroin use). Its ultimate cause(s) is (are) unknown. Characterized by both motor and non-motor symptoms, PD patients classically display rest tremor, rigidity, bradykinesia, and stooping posture. PD can also be associated with neurobehavioral disorders (depression, anxiety), cognitive impairment (dementia), and autonomic dysfunction (e.g., orthostasis and hyperhidrosis). Recent decades have witnessed a proliferation of medical pharmacologic therapies and innovative surgical interventions like deep brain stimulation (DBS). However, definitive disease-modifying therapy is still lacking. Experimental therapies are being developed and tested with limited results. Knowledge of strategies to promote optimal quality of life for PD patients is of paramount importance for caregivers, health providers and patients themselves.

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