Abstract
The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.
Original language | English (US) |
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Article number | 40 |
Journal | Cancer Communications |
Volume | 38 |
Issue number | 1 |
DOIs | |
State | Published - Jun 26 2018 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Keywords
- Cancer
- E3 ubiquitin ligase
- Parkin
- Parkinson's disease
- Tumor suppressor