Parkinson's disease-associated protein Parkin: An unusual player in cancer

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41 Scopus citations

Abstract

The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.

Original languageEnglish (US)
Article number40
JournalCancer Communications
Volume38
Issue number1
DOIs
StatePublished - Jun 26 2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Cancer
  • E3 ubiquitin ligase
  • Parkin
  • Parkinson's disease
  • Tumor suppressor

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