Partial damage to nigrostriatal bundle: compensatory changes and the action of L-dopa.

M. J. Zigmond, E. D. Abercrombie, E. M. Stricker

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Parkinson's disease is associated with degeneration of the nigrostriatal bundle. However, the neurological symptoms that accompany this disease do not emerge until the degenerative process is almost complete. Early studies with animals models suggested that the extensive preclinical phase of Parkinsonism was due in part to the development of a compensatory hyperactivity within remaining dopamine-containing neurons. Other studies suggested that systemic administration of L-DOPA could reduce the neurological symptoms once they emerged by further increasing the availability of dopamine in striatum. Subsequent work has supported both hypothesis.

Original languageEnglish (US)
Pages (from-to)217-232
Number of pages16
JournalJournal of neural transmission. Supplementum
Volume29
DOIs
StatePublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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