Participation of c-myc protein in DNA synthesis of human cells

George P. Studzinski, Zamir S. Brelvi, Susan C. Feldman, Rosemary A. Watt

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


The protein product of oncogene c-myc is believed to be important in regulation of the cell cycle. However, its direct role in DNA synthesis has not been explored. Experiments presented here show that the addition of affinity-purified antibodies against the human c-myc protein to nuclei isolated from several types of human cells reversibly inhibited DNA synthesis and DNA polymerase activity of these nuclei. This suggests that c-myc encodes a protein that is functionally involved in DNA synthesis.

Original languageEnglish (US)
Pages (from-to)467-470
Number of pages4
Issue number4775
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • General


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