Parvalbumin-containing neurons in the basal forebrain receive direct input from the substantia nigra-ventral tegmental area

Ronald P.A. Gaykema, Laszlo Zaborszky

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

By means of anterograde tracing of Phaseolus vulgaris-leucoagglutinin (PHA-L) it was determined if parvalbumin-immunoreactive neurons in the basal forebrain receive a direct synaptic input from the A9-A10 dopaminergic nuclei of the substantia nigra and ventral tegmental area. Forebrain sections were processed for immunocytochemical detection of PHA-L and parvalbumin (PV) at light and electron microscopic levels. At the ultrastructural level, PHA-L-labeled terminals were found to establish synaptic contacts with PV-immunoreactive neuronal somata in the ventromedial globus pallidus, the ventral pallidum, the internal capsule, and the substantia innominata. PV-containing neurons in pallidal and adjacent basal forebrain territories are thus directly targeted by presumably A9-A10 dopaminergic neurons and represent a novel aspect of midbrain dopaminergic control of basal forebrain neuronal activity.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalBrain research
Volume747
Issue number1
DOIs
StatePublished - Jan 30 1997

Fingerprint

Parvalbumins
Ventral Tegmental Area
Substantia Nigra
Neurons
antineoplaston A10
Substantia Innominata
Internal Capsule
Globus Pallidus
Dopaminergic Neurons
Carisoprodol
Prosencephalon
Mesencephalon
Electrons
Light
Basal Forebrain
plants leukoagglutinins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • GABA
  • Phaseolus vulgaris-leucoagglutinin
  • anterograde tracing
  • dopamine
  • substantia innominata
  • ventral pallidum

Cite this

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title = "Parvalbumin-containing neurons in the basal forebrain receive direct input from the substantia nigra-ventral tegmental area",
abstract = "By means of anterograde tracing of Phaseolus vulgaris-leucoagglutinin (PHA-L) it was determined if parvalbumin-immunoreactive neurons in the basal forebrain receive a direct synaptic input from the A9-A10 dopaminergic nuclei of the substantia nigra and ventral tegmental area. Forebrain sections were processed for immunocytochemical detection of PHA-L and parvalbumin (PV) at light and electron microscopic levels. At the ultrastructural level, PHA-L-labeled terminals were found to establish synaptic contacts with PV-immunoreactive neuronal somata in the ventromedial globus pallidus, the ventral pallidum, the internal capsule, and the substantia innominata. PV-containing neurons in pallidal and adjacent basal forebrain territories are thus directly targeted by presumably A9-A10 dopaminergic neurons and represent a novel aspect of midbrain dopaminergic control of basal forebrain neuronal activity.",
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Parvalbumin-containing neurons in the basal forebrain receive direct input from the substantia nigra-ventral tegmental area. / Gaykema, Ronald P.A.; Zaborszky, Laszlo.

In: Brain research, Vol. 747, No. 1, 30.01.1997, p. 173-179.

Research output: Contribution to journalArticle

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N2 - By means of anterograde tracing of Phaseolus vulgaris-leucoagglutinin (PHA-L) it was determined if parvalbumin-immunoreactive neurons in the basal forebrain receive a direct synaptic input from the A9-A10 dopaminergic nuclei of the substantia nigra and ventral tegmental area. Forebrain sections were processed for immunocytochemical detection of PHA-L and parvalbumin (PV) at light and electron microscopic levels. At the ultrastructural level, PHA-L-labeled terminals were found to establish synaptic contacts with PV-immunoreactive neuronal somata in the ventromedial globus pallidus, the ventral pallidum, the internal capsule, and the substantia innominata. PV-containing neurons in pallidal and adjacent basal forebrain territories are thus directly targeted by presumably A9-A10 dopaminergic neurons and represent a novel aspect of midbrain dopaminergic control of basal forebrain neuronal activity.

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