Parvalbumin-containing neurons in the basal forebrain receive direct input from the substantia nigra-ventral tegmental area

Ronald P.A. Gaykema, Laszlo Zaborszky

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

By means of anterograde tracing of Phaseolus vulgaris-leucoagglutinin (PHA-L) it was determined if parvalbumin-immunoreactive neurons in the basal forebrain receive a direct synaptic input from the A9-A10 dopaminergic nuclei of the substantia nigra and ventral tegmental area. Forebrain sections were processed for immunocytochemical detection of PHA-L and parvalbumin (PV) at light and electron microscopic levels. At the ultrastructural level, PHA-L-labeled terminals were found to establish synaptic contacts with PV-immunoreactive neuronal somata in the ventromedial globus pallidus, the ventral pallidum, the internal capsule, and the substantia innominata. PV-containing neurons in pallidal and adjacent basal forebrain territories are thus directly targeted by presumably A9-A10 dopaminergic neurons and represent a novel aspect of midbrain dopaminergic control of basal forebrain neuronal activity.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalBrain research
Volume747
Issue number1
DOIs
StatePublished - Jan 30 1997

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • GABA
  • Phaseolus vulgaris-leucoagglutinin
  • anterograde tracing
  • dopamine
  • substantia innominata
  • ventral pallidum

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