Pathogens Resistant to Antibacterial Agents

Luke F. Chen; Teena Chopra; Keith S. Kaye

doi:10.1016/j.idc.2009.06.002

Pathogens Resistant to Antibacterial Agents

Luke F. Chen, Teena Chopra, Keith S. Kaye

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. A disturbing trend has been the recent emergence and spread of resistant pathogens in nursing homes, in the community, and in the hospital. This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs.

Original language	English (US)
Pages (from-to)	817-845
Number of pages	29
Journal	Infectious Disease Clinics of North America
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.idc.2009.06.002
State	Published - Dec 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Keywords

Acinetobacter baumanii
Drug resistance
Extended-spectrum β-lactamase
Klebsiella pneumoniae carbapenemase
Methicillin-resistant Staphylococcus aureus
Penicillin-resistant Streptococcus pneumoniae
Vancomycin intermediate-susceptible Staphylococcus aureus
Vancomycin-resistant Enterococcus

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10.1016/j.idc.2009.06.002

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title = "Pathogens Resistant to Antibacterial Agents",

abstract = "Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. A disturbing trend has been the recent emergence and spread of resistant pathogens in nursing homes, in the community, and in the hospital. This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs.",

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year = "2009",

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T1 - Pathogens Resistant to Antibacterial Agents

AU - Chen, Luke F.

AU - Chopra, Teena

AU - Kaye, Keith S.

PY - 2009/12

Y1 - 2009/12

N2 - Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. A disturbing trend has been the recent emergence and spread of resistant pathogens in nursing homes, in the community, and in the hospital. This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs.

AB - Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. A disturbing trend has been the recent emergence and spread of resistant pathogens in nursing homes, in the community, and in the hospital. This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs.

KW - Acinetobacter baumanii

KW - Drug resistance

KW - Extended-spectrum β-lactamase

KW - Klebsiella pneumoniae carbapenemase

KW - Methicillin-resistant Staphylococcus aureus

KW - Penicillin-resistant Streptococcus pneumoniae

KW - Vancomycin intermediate-susceptible Staphylococcus aureus

KW - Vancomycin-resistant Enterococcus

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U2 - 10.1016/j.idc.2009.06.002

DO - 10.1016/j.idc.2009.06.002

M3 - Review article

C2 - 19909886

AN - SCOPUS:71049190564

SN - 0891-5520

VL - 23

SP - 817

EP - 845

JO - Infectious Disease Clinics of North America

JF - Infectious Disease Clinics of North America

IS - 4

ER -

Pathogens Resistant to Antibacterial Agents

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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