Pathophysiological effects of activation of renin angiotensin system

C. R. Benedict, John Kostis

Research output: Contribution to journalReview article


Despite the advances in understanding the progression of hypertension and involvement of target organs, therapeutic options for these patients remains inadequate. For example, diuretics reduce incidence of stroke and development of heart failure but not total mortality. In contrast, randomized control trials with ACE inhibitors indicates the importance of renin angiotensin system in progression of cardiac, vasclar, and renal damage in hypertensive patients. This paper summarizes the known mechanisms, their site of action, and their role in development of complications in hypertensive patients. (C) 2000 by Le Jacq Communications, Inc.

Original languageEnglish (US)
Pages (from-to)65-68
Number of pages4
JournalDisease Management and Clinical Outcomes
Issue number1-2
StatePublished - Jan 1 2000
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

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