Pathophysiological functions of nitric oxide-mediated protein modifications

Harry Ischiropoulos, Andrew Gow

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Specific post-translational modifications resulting from the reaction of nitric oxide or nitric oxide-derived reactive nitrogen species with selective proteins may explain the pleiotropic effects of this molecule in biological systems. Three specific reactions, binding to metal centers, nitrosation of nucleophilic centers and nitration of aromatic residues constitute a major component of the biological reactivity of nitric oxide. We postulate that the chemical reactivity of nitric oxide within biological systems allows this simple diatomic molecule to operate as an integrator of physiological homeostasis and potentially under not completely understood circumstances as a mediator of pathological phenotypes. This chapter reviews the chemistry, putative biological functions and significance of the principal nitric oxide-mediated proteins modifications.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalToxicology
Volume208
Issue number2
DOIs
StatePublished - Mar 15 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Toxicology

Keywords

  • Nitric oxide
  • Pathophysiological functions
  • Protein

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