Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Tetsuro Ago, Junya Kuroda, Masahiro Kamouchi, Junichi Sadoshima, Takanari Kitazono

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

Original languageEnglish (US)
Pages (from-to)1791-1800
Number of pages10
JournalCirculation Journal
Volume75
Issue number8
DOIs
StatePublished - Aug 1 2011

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Keywords

  • NADPH oxidase/Nox
  • Reactive oxygen species
  • Vascular diseases

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