Pathway index models for construction of patient-specific risk profiles

Kevin H. Eng, Sijian Wang, William H. Bradley, Janet S. Rader, Christina Kendziorski

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Statistical methods for variable selection, prediction, and classification have proven extremely useful in moving personalized genomics medicine forward, in particular, leading to a number of genomic-based assays now in clinical use for predicting cancer recurrence. Although invaluable in individual cases, the information provided by these assays is limited. Most often, a patient is classified into one of very few groups (e.g., recur or not), limiting the potential for truly personalized treatment. Furthermore, although these assays provide information on which individuals are at most risk (e.g., those for which recurrence is predicted), they provide no information on the aberrant biological pathways that give rise to the increased risk. We have developed an approach to address these limitations. The approach models a time-to-event outcome as a function of known biological pathways, identifies important genomic aberrations, and provides pathway-based patient-specific assessments of risk. As we demonstrate in a study of ovarian cancer from The Cancer Genome Atlas project, the patient-specific risk profiles are powerful and efficient characterizations useful in addressing a number of questions related to identifying informative patient subtypes and predicting survival.

Original languageEnglish (US)
Pages (from-to)1524-1535
Number of pages12
JournalStatistics in Medicine
Issue number9
StatePublished - Apr 30 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Statistics and Probability


  • Gene expression
  • Genomic analysis
  • Molecular profiling
  • Ovarian cancer
  • Survival analysis


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