PBP4 mediates-lactam resistance by altered function

Som S. Chatterjee; Liang Chen; Aubre Gilbert; Thaina M. Da Costa; Vinod Nair; Sandip K. Datta; Barry N. Kreiswirth; Henry F. Chambers

doi:10.1128/AAC.00932-17

PBP4 mediates-lactam resistance by altered function

Som S. Chatterjee, Liang Chen, Aubre Gilbert, Thaina M. Da Costa, Vinod Nair, Sandip K. Datta, Barry N. Kreiswirth, Henry F. Chambers

New Jersey Medical School (NJMS), Public Health Research Institute Center

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Penicillin binding protein 4 (PBP4) can provide high-level -lactam resistance in Staphylococcus aureus. A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the -lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of pbp4. Our results also suggest a cooperative interplay among PBPs for -lactam resistance.

Original language	English (US)
Article number	e00932-17
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00932-17
State	Published - Nov 2017

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

Keywords

-lactam resistance
PBP4
Staphylococcus aureus

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10.1128/AAC.00932-17

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abstract = "Penicillin binding protein 4 (PBP4) can provide high-level -lactam resistance in Staphylococcus aureus. A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the -lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of pbp4. Our results also suggest a cooperative interplay among PBPs for -lactam resistance.",

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AU - Chen, Liang

AU - Gilbert, Aubre

AU - Da Costa, Thaina M.

AU - Nair, Vinod

AU - Datta, Sandip K.

AU - Kreiswirth, Barry N.

AU - Chambers, Henry F.

PY - 2017/11

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AB - Penicillin binding protein 4 (PBP4) can provide high-level -lactam resistance in Staphylococcus aureus. A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the -lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of pbp4. Our results also suggest a cooperative interplay among PBPs for -lactam resistance.

KW - -lactam resistance

KW - PBP4

KW - Staphylococcus aureus

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ER -

PBP4 mediates-lactam resistance by altered function

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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