PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

Richard Torres, Bonnie Firestein-Miller, Hualing Dong, Jeff Staudinger, Eric N. Olson, Richard L. Huganir, David S. Bredt, Nicholas W. Gale, George D. Yancopoulos

Research output: Contribution to journalArticlepeer-review

389 Scopus citations

Abstract

Localizing cell surface receptors to specific subcellular positions can be critical for their proper functioning, as most notably demonstrated at neuronal synapses. PDZ proteins apparently play critical roles in such protein localizations. Receptor tyrosine kinases have not been previously shown to interact with PDZ proteins in vertebrates. We report that Eph receptors and their membrane-linked ligands all contain PDZ recognition motifs and can bind and be clustered by PDZ proteins. In addition, we find that Eph receptors and ligands colocalize with PDZ proteins at synapses. Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse.

Original languageEnglish (US)
Pages (from-to)1453-1463
Number of pages11
JournalNeuron
Volume21
Issue number6
DOIs
StatePublished - Dec 1998

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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