Pediatric COVID-19 and Appendicitis: A Gut Reaction to SARS-CoV-2?

Amisha Malhotra, Marc Sturgill, Patricia Whitley-Williams, Yi Horng Lee, Chika Esochaghi, Hariprem Rajasekhar, Birk Olson, Sunanda Gaur

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: We describe the temporal pattern of COVID-19 admissions to a tertiary care children's hospital in central New Jersey during the SARS-CoV-2 surge, covering the time period from March 29 to July 26, 2020. Methods: Medical charts were reviewed for the date of admission, past medical history, and demographic variables, presenting signs and symptoms, admitting laboratory values, diagnostic imaging, diagnosis, treatment modalities, and outcomes including length of stay and disease severity. Results: Patients with symptomatic SARS-CoV-2 infection tended to present with pneumonia early during the study period, which coincided with the early surge in New Jersey cases. Approximately 2 weeks after the peak in reported SARS-CoV-2 cases in New Jersey, we began to see fewer pneumonia cases and an increase in admissions for Multi-Inflammatory Syndrome in Children and cases of acute appendicitis in association with a diagnosis of SARS-CoV-2 infection. Conclusions: We present a novel association of acute appendicitis in children infected with SARS-CoV-2 and postulate that it may represent a postinfectious hyperinflammatory complication of SARS-CoV-2 infection occurring 2 weeks after the early manifestation of acute pneumonia disease in children.

Original languageEnglish (US)
Pages (from-to)E49-E55
JournalPediatric Infectious Disease Journal
StatePublished - Feb 1 2021

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases


  • COVID-19
  • MIS-C
  • SARS-CoV-2
  • appendicitis
  • children
  • pneumonia


Dive into the research topics of 'Pediatric COVID-19 and Appendicitis: A Gut Reaction to SARS-CoV-2?'. Together they form a unique fingerprint.

Cite this