Penta-O-galloyl-β-d-glucose suppresses EGF-induced eIF3i expression through inhibition of the PI3K/AKT/mTOR pathway in prostate cancer cells

Victor Chia Hsiang Lin, Po Tsun Kuo, Ying Chao Lin, Yeh Chen, You Cheng Hseu, Hsin Ling Yang, Jung Yie Kao, Chi Tang Ho, Tzong Der Way

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Approximately 70% of prostate cancer patients will develop bone metastasis in axial and other regions of the skeleton. Epidermal growth factor (EGF) generated from bone tissue contributes to prostate cancer metastasis. In a previous study, penta-O-galloyl-β-d-glucose (PGG) suppressed androgen-independent prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression. This study utilized proteomics to analyze the effects of PGG in EGF-induced prostate cancer bone metastasis. This study showed that PGG suppressed EGF-induced eIF3i expression in PC-3 cells. By transfection of eIF3i shRNA, it was observed that reduced eIF3i expression suppressed the invasion of PC-3 cells in vitro. PGG reduced EGF-induced eIF3i expression through inhibition of the PI3K/AKT/mTOR pathway. Therefore, PGG may be able to be used as a potential new therapeutic drug for prostate cancer bone metastasis.

Original languageEnglish (US)
Pages (from-to)8990-8996
Number of pages7
JournalJournal of agricultural and food chemistry
Volume62
Issue number36
DOIs
StatePublished - Sep 10 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • EGF
  • PGG
  • PI3K/AKT/mTOR
  • bone metastasis
  • prostate cancer

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