Peptide dependence of major histocompatibility complex class II specific alloreactive responses

D. Vidović, J. I. Toral, D. R. Bolin, K. Ito, Z. A. Nagy

Research output: Contribution to journalArticlepeer-review

Abstract

Splenic cells from transgenic mice, in which a single peptide is complexed to all major histocompatibility complex (MHC) class II molecules, are found to be incapable of triggering primary allogeneic mixed lymphocyte/leucocyte reactions (MLR) when co-cultured with lymphocytes from MHC class II congenic mouse strains. In addition, a single HLA-DR-blocking peptide can completely abrogate the capacity of splenocytes from chimeric HLA-DR/H2-E transgenic mice to stimulate primary MLR of T cells from wild- type mice. These results indicate that the primary alloreactive response is directed against a multitude of peptides presented by allogeneic MHC molecules.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalScandinavian Journal of Immunology
Volume47
Issue number3
DOIs
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Immunology

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