TY - JOUR
T1 - Periodontal disease in hypothyroid adult rats
AU - Schneider, L. C.
N1 - Funding Information:
LEON KRAINTZo f the Universityo f British Columbia. This work wass upportedin part by USPHS PostdoctoralF ellowshipA ward 4-F2-DE-28,468,f rom the National Instituteo f Dental Research,a nd was performeda s partial fulfillmento f requirementfso r the Ph.D. degreeN, orthwesternU niversity.
PY - 1969/10
Y1 - 1969/10
N2 - Parathyroid glands were autotransplanted to the thigh muscle in both experimental and control rats, and at this time thyroidectomies were also performed upon the experimental group. The serum calcium range exhibited by intact fasted rats was employed as the index of normal parathyroid function, and parathyroid autotransplanted rats having a fasted serum calcium below this range 2 weeks after surgery were rejected; animals retained, therefore, possessed functioning parathyroid tissue. Removal of thyroid tissue and reduction of iodothyronines in the experimental rats was demonstrated by 24-hr iodine131 uptake, rate of oxygen consumption, and protein-bound iodine. Thirty-two experimental rats and 25 controls survived until sacrifice, 10 months after surgery. Periodontal tissue was assessed by light microscopic examination of sections of the molar regions of the maxilla and mandible prepared by several techniques. The control and experimental rats were susceptible to inflammatory periodontal disease, but a higher incidence could not be demonstrated in the hypothyroid animals. There was no evidence of degenerative periodontal change in the experimental rats. These animals were deficient in thyrocalcitonin (which opposes the resorptive action of parathyroid hormone on bone) and possessed functioning parathyroid glands, but increased resorption of alveolar bone did not occur.
AB - Parathyroid glands were autotransplanted to the thigh muscle in both experimental and control rats, and at this time thyroidectomies were also performed upon the experimental group. The serum calcium range exhibited by intact fasted rats was employed as the index of normal parathyroid function, and parathyroid autotransplanted rats having a fasted serum calcium below this range 2 weeks after surgery were rejected; animals retained, therefore, possessed functioning parathyroid tissue. Removal of thyroid tissue and reduction of iodothyronines in the experimental rats was demonstrated by 24-hr iodine131 uptake, rate of oxygen consumption, and protein-bound iodine. Thirty-two experimental rats and 25 controls survived until sacrifice, 10 months after surgery. Periodontal tissue was assessed by light microscopic examination of sections of the molar regions of the maxilla and mandible prepared by several techniques. The control and experimental rats were susceptible to inflammatory periodontal disease, but a higher incidence could not be demonstrated in the hypothyroid animals. There was no evidence of degenerative periodontal change in the experimental rats. These animals were deficient in thyrocalcitonin (which opposes the resorptive action of parathyroid hormone on bone) and possessed functioning parathyroid glands, but increased resorption of alveolar bone did not occur.
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U2 - 10.1016/0003-9969(69)90156-3
DO - 10.1016/0003-9969(69)90156-3
M3 - Article
C2 - 4187861
AN - SCOPUS:0014581315
SN - 0003-9969
VL - 14
SP - 1169
EP - 1175
JO - Archives of Oral Biology
JF - Archives of Oral Biology
IS - 10
ER -