Peripheral CD4 T Cells Rapidly Accumulate at the Host:Parasite, Interface during an Inflammatory Th2 Memory Response

Motoko Morimoto, Masahiro Morimoto, Jeannette Whitmire, Shiyun Xiao, Robert M. Anthony, Hiroshi Mirakami, Robert A. Star, Joseph F. Urban, William C. Gause

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Memory peripheral Th2 immune responses to infectious pathogens are not well studied due to the lack of suitable models and the difficulty of assessing Th2 cytokine expression at sites of inflammation. We have examined the localized immune response to a nematode parasite that encysts in the small intestine. An unexpected architecture was observed on day 4 of the memory response, with granulocytes and macrophages infiltrating the cyst and CD4 +, TCR-αβ+ T cells surrounding the cyst. Laser capture microdissection analysis showed a pronounced CD4-dependent Th2 cytokine pattern at the cyst region only during the memory response, demonstrating that the Th2 memory response is readily distinguished from the primary response by the rapid accumulation of Th2 effector cells at the host:parasite interface.

Original languageEnglish (US)
Pages (from-to)2424-2430
Number of pages7
JournalJournal of Immunology
Volume172
Issue number4
DOIs
StatePublished - Feb 15 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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