TY - JOUR
T1 - Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin
AU - Bozdagi, Ozlem
AU - Wang, Xiao Bin
AU - Nikitczuk, Jessica S.
AU - Anderson, Tonya R.
AU - Bloss, Erik B.
AU - Radice, Glenn L.
AU - Zhou, Qiang
AU - Benson, Deanna L.
AU - Huntley, George W.
PY - 2010/7/28
Y1 - 2010/7/28
N2 - Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal ablation of N-cadherin has profound effects on the stability of coordinated spine enlargement and long-term potentiation (LTP) at mature CA1 synapses, with no effects on baseline spine density or morphology, baseline properties of synaptic neurotransmission, or long-term depression. Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic functional modifications associated selectively with LTP, revealing unexpectedly distinct roles at mature synapses in comparison with earlier, broader functions in synapse and spine development.
AB - Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal ablation of N-cadherin has profound effects on the stability of coordinated spine enlargement and long-term potentiation (LTP) at mature CA1 synapses, with no effects on baseline spine density or morphology, baseline properties of synaptic neurotransmission, or long-term depression. Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic functional modifications associated selectively with LTP, revealing unexpectedly distinct roles at mature synapses in comparison with earlier, broader functions in synapse and spine development.
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U2 - 10.1523/JNEUROSCI.1223-10.2010
DO - 10.1523/JNEUROSCI.1223-10.2010
M3 - Article
C2 - 20668183
AN - SCOPUS:77955401793
SN - 0270-6474
VL - 30
SP - 9984
EP - 9989
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 30
ER -