Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin

Maria Sjölund, Eva Tano, Martin J. Blaser, Dan I. Andersson, Lars Engstrand

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epidermidis strains were isolated and analyzed for clarithromycin susceptibility and presence of the erm(C) gene. We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment.

Original languageEnglish (US)
Pages (from-to)1389-1393
Number of pages5
JournalEmerging Infectious Diseases
Issue number9
StatePublished - Sep 2005

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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