Perspective: Adhesion mediated signal transduction in bacterial pathogens

Sudha Moorthy, Julia Keklak, Eric A. Klein

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


During the infection process, pathogenic bacteria undergo large-scale transcriptional changes to promote virulence and increase intrahost survival. While much of this reprogramming occurs in response to changes in chemical environment, such as nutrient availability and pH, there is increasing evidence that adhesion to host-tissue can also trigger signal transduction pathways resulting in differential gene expression. Determining the molecular mechanisms of adhesion-mediated signaling requires disentangling the contributions of chemical and mechanical stimuli. Here we highlight recent work demonstrating that surface attachment drives a transcriptional response in bacterial pathogens, including uropathogenic Escherichia coli (E. coli), and discuss the complexity of experimental design when dissecting the specific role of adhesion-mediated signaling during infection.

Original languageEnglish (US)
Article number23
Issue number1
StatePublished - Feb 18 2016

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases


  • Adhesion
  • Fimbriae
  • Signal transduction
  • Uropathogenic E. Coli
  • Virulence


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