Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker

G. Buzsáki; A. Smith; S. Berger; L. J. Fisher; F. H. Gage; G. Aston-Jones; F. E. Bloom

doi:10.1016/0306-4522(90)90345-5

Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker

G. Buzsáki, A. Smith, S. Berger, L. J. Fisher, F. H. Gage, G. Aston-Jones, F. E. Bloom

Research output: Contribution to journal › Comment/debate › peer-review

182 Scopus citations

Abstract

Rhythmic oscillation in neuronal systems may serve physiological purposes or may interfere with normal functions of the brain. In disorders of petit mal epilepsy and parkinsonian tremor, centrally and peripherally observable rhythmic patterns are due to network oscillations of thalamocortical cells. This article reviews the afferent mechanisms that might be critically involved in controlling the ionic conductances of thalamic neurons in the behaving organism. We propose that during active behavior the subcortical aminergic and cholinergic inputs to the thalamus act as anti-burst and anti-oscillation mechanisms. We suggest further that the thalamopetal GABAergic.

Original language	English (US)
Pages (from-to)	1-14
Number of pages	14
Journal	Neuroscience
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0306-4522(90)90345-5
State	Published - 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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title = "Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker",

abstract = "Rhythmic oscillation in neuronal systems may serve physiological purposes or may interfere with normal functions of the brain. In disorders of petit mal epilepsy and parkinsonian tremor, centrally and peripherally observable rhythmic patterns are due to network oscillations of thalamocortical cells. This article reviews the afferent mechanisms that might be critically involved in controlling the ionic conductances of thalamic neurons in the behaving organism. We propose that during active behavior the subcortical aminergic and cholinergic inputs to the thalamus act as anti-burst and anti-oscillation mechanisms. We suggest further that the thalamopetal GABAergic.",

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T1 - Petit mal epilepsy and parkinsonian tremor

T2 - Hypothesis of a common pacemaker

AU - Buzsáki, G.

AU - Smith, A.

AU - Berger, S.

AU - Fisher, L. J.

AU - Gage, F. H.

AU - Aston-Jones, G.

AU - Bloom, F. E.

PY - 1990

Y1 - 1990

N2 - Rhythmic oscillation in neuronal systems may serve physiological purposes or may interfere with normal functions of the brain. In disorders of petit mal epilepsy and parkinsonian tremor, centrally and peripherally observable rhythmic patterns are due to network oscillations of thalamocortical cells. This article reviews the afferent mechanisms that might be critically involved in controlling the ionic conductances of thalamic neurons in the behaving organism. We propose that during active behavior the subcortical aminergic and cholinergic inputs to the thalamus act as anti-burst and anti-oscillation mechanisms. We suggest further that the thalamopetal GABAergic.

AB - Rhythmic oscillation in neuronal systems may serve physiological purposes or may interfere with normal functions of the brain. In disorders of petit mal epilepsy and parkinsonian tremor, centrally and peripherally observable rhythmic patterns are due to network oscillations of thalamocortical cells. This article reviews the afferent mechanisms that might be critically involved in controlling the ionic conductances of thalamic neurons in the behaving organism. We propose that during active behavior the subcortical aminergic and cholinergic inputs to the thalamus act as anti-burst and anti-oscillation mechanisms. We suggest further that the thalamopetal GABAergic.

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AN - SCOPUS:0025315068

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ER -

Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker

Abstract

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