D. L. Laskin, C. R. Gardner, J. D. Laskin

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Accumulating evidence suggests that phagocytic cells of the innate immune system, including neutrophils and macrophages, play an important role in the pathogenesis of tissue injury in response to diverse toxicants. Through the release of proinflammatory and cytotoxic oxidants, cytokines, proteases, and bioactive lipids, these cells can contribute to tissue damage. More recent studies suggest that, at later times following injury, macrophages and mediators they generate also play a key role in downregulating the inflammatory response and initiating tissue repair. These divergent activities appear to be mediated by a distinct subpopulation of macrophages. It is apparent that the outcome of inflammatory responses to tissue injury depends on the balance between the pro- and anti-inflammatory actions of these cells. Elucidating the contribution of phagocytes and inflammatory mediators to tissue injury and repair may help in the design of new and effective approaches to mitigating xenobiotic-induced pathologies.

Original languageEnglish (US)
Title of host publicationImmune System Toxicology
PublisherElsevier Inc.
Number of pages21
ISBN (Print)9780080468686
StatePublished - Aug 12 2010

All Science Journal Classification (ASJC) codes

  • Medicine(all)


  • Cytokines
  • Eicosanoids
  • Inflammation
  • Macrophages
  • Neutrophils
  • Nitric oxide
  • Reactive nitrogen species
  • Reactive oxygen species


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