Pharmacokinetic characterization of extracorporeal therapy

Henrik Pedersen, Csaba Horváth

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The efficiency of extracorporeal therapy with immobilized enzymes (reactive devices) and hemoperfusion cartridges (nonreactive devices) is evaluated in terms of a new pharmacokinetic parameter, the bioefficacy. A detailed analysis is provided in the former case, and it is shown how the bioefficacy can be calculated from a combined pharmacokinetic and reactor analysis. The theory is presented for evaluating bioefficacy in terms of linear pharmacokinetic models that view the reactor or other extracorporeal appliance as an artificial organ. Examples are drawn from recent work on methotrexate rescue with immobilized carboxypeptidase G1 and from literature data on the use of hemoperfusion to treat drug overdose to illustrate the calculations.

Original languageEnglish (US)
Pages (from-to)437-454
Number of pages18
JournalJournal of Pharmacokinetics and Biopharmaceutics
Issue number4
StatePublished - Aug 1982

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


  • artificial organs
  • bioefficacy
  • enzyme therapy
  • hemoperfusion
  • immobilized enzymes


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