Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration

R. L. Moldow, Kevin Beck, G. Zhu, D. Beldowicz, F. X. Brennan, J. E. Ottenweller, R. J. Servatius

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Elevated basal plasma corticosterone concentrations have been observed for several days after the cessation of severe stress. In the present study, we examined whether or not the acute plasma corticosterone response to stress is necessary to elicit increased basal plasma corticosterone concentrations the following day. Pretreatment with metyrapone (100 mg/kg, intraperitoneal) 1 h before inescapable stress (40 2mA tailshocks delivered over a 1-h period) (IS) blocked the acute plasma corticosterone response to IS. However, elevated basal plasma corticosterone concentrations still emerged the next day. These results suggest that the corticosterone response to stress, and its attendant feedback, are not necessary to produce persistent hypothalamic-pituitary-adrenal axis (HPAA) activation.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalStress
Volume4
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Corticosterone
Pharmacology
Metyrapone

All Science Journal Classification (ASJC) codes

  • Physiology
  • Neuropsychology and Physiological Psychology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Moldow, R. L. ; Beck, Kevin ; Zhu, G. ; Beldowicz, D. ; Brennan, F. X. ; Ottenweller, J. E. ; Servatius, R. J. / Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration. In: Stress. 2001 ; Vol. 4, No. 2. pp. 137-141.
@article{902837180a73428180b5b5e74e3cafd2,
title = "Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration",
abstract = "Elevated basal plasma corticosterone concentrations have been observed for several days after the cessation of severe stress. In the present study, we examined whether or not the acute plasma corticosterone response to stress is necessary to elicit increased basal plasma corticosterone concentrations the following day. Pretreatment with metyrapone (100 mg/kg, intraperitoneal) 1 h before inescapable stress (40 2mA tailshocks delivered over a 1-h period) (IS) blocked the acute plasma corticosterone response to IS. However, elevated basal plasma corticosterone concentrations still emerged the next day. These results suggest that the corticosterone response to stress, and its attendant feedback, are not necessary to produce persistent hypothalamic-pituitary-adrenal axis (HPAA) activation.",
author = "Moldow, {R. L.} and Kevin Beck and G. Zhu and D. Beldowicz and Brennan, {F. X.} and Ottenweller, {J. E.} and Servatius, {R. J.}",
year = "2001",
month = "1",
day = "1",
doi = "10.3109/10253890109115727",
language = "English (US)",
volume = "4",
pages = "137--141",
journal = "Stress",
issn = "1025-3890",
publisher = "Informa Healthcare",
number = "2",

}

Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration. / Moldow, R. L.; Beck, Kevin; Zhu, G.; Beldowicz, D.; Brennan, F. X.; Ottenweller, J. E.; Servatius, R. J.

In: Stress, Vol. 4, No. 2, 01.01.2001, p. 137-141.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration

AU - Moldow, R. L.

AU - Beck, Kevin

AU - Zhu, G.

AU - Beldowicz, D.

AU - Brennan, F. X.

AU - Ottenweller, J. E.

AU - Servatius, R. J.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Elevated basal plasma corticosterone concentrations have been observed for several days after the cessation of severe stress. In the present study, we examined whether or not the acute plasma corticosterone response to stress is necessary to elicit increased basal plasma corticosterone concentrations the following day. Pretreatment with metyrapone (100 mg/kg, intraperitoneal) 1 h before inescapable stress (40 2mA tailshocks delivered over a 1-h period) (IS) blocked the acute plasma corticosterone response to IS. However, elevated basal plasma corticosterone concentrations still emerged the next day. These results suggest that the corticosterone response to stress, and its attendant feedback, are not necessary to produce persistent hypothalamic-pituitary-adrenal axis (HPAA) activation.

AB - Elevated basal plasma corticosterone concentrations have been observed for several days after the cessation of severe stress. In the present study, we examined whether or not the acute plasma corticosterone response to stress is necessary to elicit increased basal plasma corticosterone concentrations the following day. Pretreatment with metyrapone (100 mg/kg, intraperitoneal) 1 h before inescapable stress (40 2mA tailshocks delivered over a 1-h period) (IS) blocked the acute plasma corticosterone response to IS. However, elevated basal plasma corticosterone concentrations still emerged the next day. These results suggest that the corticosterone response to stress, and its attendant feedback, are not necessary to produce persistent hypothalamic-pituitary-adrenal axis (HPAA) activation.

UR - http://www.scopus.com/inward/record.url?scp=0034803132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034803132&partnerID=8YFLogxK

U2 - 10.3109/10253890109115727

DO - 10.3109/10253890109115727

M3 - Article

VL - 4

SP - 137

EP - 141

JO - Stress

JF - Stress

SN - 1025-3890

IS - 2

ER -