Phase shifting of the circadian clock by induction of the Drosophila period protein

Isaac Edery, Joan E. Rutila, Michael Rosbash

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Virtually all organisms manifest circadian (24-hour) rhythms, governed by an ill-defined endogenous pacemaker or clock. Several lines of evidence suggest that the Drosophila melanogaster period gene product PER is a clock component. If PER were central to the time-keeping mechanism, a transient increase in its concentration would cause a stable shift in the phase of the clock. Therefore, transgenic flies bearing a heat-inducible copy of PER were subjected to temperature pulses. This treatment caused long-lasting phase shifts in the locomotor activity circadian rhythm, a result that supports the contention that PER is a bona fide clock component.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalScience
Volume263
Issue number5144
DOIs
StatePublished - Jan 14 1994

All Science Journal Classification (ASJC) codes

  • General

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