TY - JOUR
T1 - Phencyclidine Sedation as a Technique for Handling Rhesus Monkeys
T2 - Effects on LH, GH, and Prolactin Secretion
AU - Ferin, Michel
AU - Carmel, Peter W.
AU - Warren, Michelle P.
AU - Himsworth, Richard L.
AU - Frantz, Andrew G.
N1 - Funding Information:
Supported by NIH Grants Nos. 1P01-HD-06132, 1P01-HD-05077, CA-11704, CA-13696, and Ford Foundation Grant No. 660-0032. 2
PY - 1976/2
Y1 - 1976/2
N2 - Rhesus monkeys, sedated with phencyclidine hydrochloride (Sernylan), were quieted for prolonged periods of time, while maintaining somatic reflexes, muscle tone, and respiration. Brief daily periods of sedation did not interfere with the menstrual cycle. Prolonged sedation, however, interfered with the experimentally estrogen-induced LH surge, but not with the inhibitory action of estrogen on LH tonic secretion. Pulsatile release of LH, GH, and prolactin persisted even under prolonged sedation. The secretion of prolactin in response to the administration of TRH was increased in animals sedated with phencyclidine. We would like to thank Mr. Paul Diefenbach and Mr. Howard Rosenblatt for their help in handling the animals; Mr. Robert Sundeen, Mrs. I. Conwell, Mrs. U. Bruce, and Miss Jane Drewes for help in RIA procedures; and Mrs. Joan Camacho for typing the manuscript. We would also like to thank the NIAMD for synthetic Gn-RH, Dr. G. Niswender for providing us with antiovine LH serum, and Dr. L. Reichert for providing us with ovine LH and LH-LER-1213.
AB - Rhesus monkeys, sedated with phencyclidine hydrochloride (Sernylan), were quieted for prolonged periods of time, while maintaining somatic reflexes, muscle tone, and respiration. Brief daily periods of sedation did not interfere with the menstrual cycle. Prolonged sedation, however, interfered with the experimentally estrogen-induced LH surge, but not with the inhibitory action of estrogen on LH tonic secretion. Pulsatile release of LH, GH, and prolactin persisted even under prolonged sedation. The secretion of prolactin in response to the administration of TRH was increased in animals sedated with phencyclidine. We would like to thank Mr. Paul Diefenbach and Mr. Howard Rosenblatt for their help in handling the animals; Mr. Robert Sundeen, Mrs. I. Conwell, Mrs. U. Bruce, and Miss Jane Drewes for help in RIA procedures; and Mrs. Joan Camacho for typing the manuscript. We would also like to thank the NIAMD for synthetic Gn-RH, Dr. G. Niswender for providing us with antiovine LH serum, and Dr. L. Reichert for providing us with ovine LH and LH-LER-1213.
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U2 - 10.3181/00379727-151-39227
DO - 10.3181/00379727-151-39227
M3 - Article
C2 - 814551
AN - SCOPUS:0017274342
SN - 0037-9727
VL - 151
SP - 428
EP - 433
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -