Phenylalanine depletion for the management of phenylketonuria: Use of enzyme reactors with immobilized enzymes

Clara M. Ambrus, Julian L. Ambrus, Csaba Horvath, Henrik Pedersen, Satya Sharma, Christopher Kant, Edwin Mirand, Robert Guthrie, Thomas Paul

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Multitubular enzyme reactors with immobilized phenylalanine ammonia lyase were tested in vitro and in vivo for depletion of phenylalanine in circulating blood. Sustained reduction of phenylalanine was achieved in less than 30 minutes. A 50 percent decrease of phenylalanine was obtained with a 2-hour application of enzyme reactors and was maintained for more than 2 days. Similar enzyme reactors have therapeutic potential for temporary management of phenylketonuric patients when their circulating phenylalanine becomes exceedingly high because of infection, fever, or pregnancy.

Original languageEnglish (US)
Pages (from-to)837-839
Number of pages3
JournalScience
Volume201
Issue number4358
DOIs
StatePublished - 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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