Phosphatidylserine suppresses myelin-lnduced experimental allergic neuritis (EAN) in lewis rats

Y. Maeda, R. Maeda, J. W. Prineas, R. W. Ledeen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Phosphatidylserine administered as an aqueous dispersion to myelin-induced experimental allergic neuritis rats had a significant effect on disease course. Intraperitoneal injections of 30 mg/kg were given daily beginning at the onset of disease and continued for 14 days. Clinical severity and mortality were markedly reduced by this treatment as compared to saline controls. Improved clinical outcome was associated with a reduction in peripheral nerve pathology. A possible mechanism involving tumor necrosis factor is discussed.

Original languageEnglish (US)
Pages (from-to)672-677
Number of pages6
JournalJournal of Neuropathology and Experimental Neurology
Volume53
Issue number6
DOIs
StatePublished - Nov 1994

All Science Journal Classification (ASJC) codes

  • General Medicine

Keywords

  • Axonal degeneration
  • Demyelination
  • Experimental allergic neuritis
  • Phosphatidylserine
  • Tumor necrosis factor

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