Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid - mediated clearance of mycobacterium tuberculosis in rabbit lungs

Medicine & Life Sciences

• CC 3052 100%
• Type 4 Cyclic Nucleotide Phosphodiesterase 76%
• Isoniazid 59%
• Mycobacterium tuberculosis 51%
• Rabbits 37%
• Gene Expression 31%
• Lung 28%
• Phosphodiesterase 4 Inhibitors 25%
• Tuberculosis 21%
• Down-Regulation 12%
• Macrophages 12%
• Macrophage Activation 10%
• Pulmonary Tuberculosis 9%
• Oligonucleotide Array Sequence Analysis 9%
• Anti-Infective Agents 8%
• Duration of Therapy 8%
• Innate Immunity 8%
• Therapeutics 7%
• Immunity 7%
• Tumor Necrosis Factor-alpha 6%
• Bacteria 5%
• Anti-Bacterial Agents 5%

Agriculture & Biology

• isoniazid 73%
• Mycobacterium tuberculosis 62%
• lungs 41%
• tuberculosis 39%
• rabbits 35%
• gene expression 31%
• macrophages 15%
• macrophage activation 12%
• DNA microarrays 9%
• tumor necrosis factor-alpha 9%
• innate immunity 8%
• dormancy 8%
• immunity 7%
• immune response 7%
• therapeutics 6%
• anti-infective agents 6%
• antibiotics 6%
• drugs 5%
• duration 5%
• pathogens 5%