Phosphoinositide 3-Kinase in Asthma: Novel roles and therapeutic approaches

Edwin J. Yoo, Christie A. Ojiaku, Krishna Sunder, Reynold A. Panettieri

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Asthma manifests as airway hyperresponsiveness and inflammation, including coughing, wheezing, and shortness of breath. Immune cells and airway structural cells orchestrate asthma pathophysiology, leading to mucus secretion, airway narrowing, and obstruction. Phosphoinositide 3-kinase, a lipid kinase, plays a crucial role in many of the cellular and molecular mechanisms driving asthma pathophysiology and represents an attractive therapeutic target. Here, we summarize the diverse roles of phosphoinositide 3-kinase in the pathogenesis of asthma and discuss novel therapeutic approaches to treatment.

Original languageEnglish (US)
Pages (from-to)700-707
Number of pages8
JournalAmerican journal of respiratory cell and molecular biology
Volume56
Issue number6
DOIs
StatePublished - Jun 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

Keywords

  • Asthma
  • Bronchodilator
  • Inflammation
  • Phosphoinositide 3-kinase

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