TY - JOUR
T1 - Phosphoinositide regulation of non-canonical transient receptor potential channels
AU - Rohacs, Tibor
N1 - Funding Information:
I thank all members of my laboratory for discussions and Dr. Martha Nowycky for helpful comments on the manuscript. The work in the author's laboratory was supported by the Alexander and Alexandrine Sinsheimer Foundation, the UMDNJ Foundation and the National Institutes of Health Grant NS055159.
PY - 2009/6
Y1 - 2009/6
N2 - Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP2, or PtdIns(4,5)P2] recently emerged as regulators of many TRP channels. Several TRP channels require PIP2 for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.
AB - Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP2, or PtdIns(4,5)P2] recently emerged as regulators of many TRP channels. Several TRP channels require PIP2 for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.
KW - PIP
KW - Phosphoinositides
KW - TRP channels
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U2 - 10.1016/j.ceca.2009.03.011
DO - 10.1016/j.ceca.2009.03.011
M3 - Review article
C2 - 19376575
AN - SCOPUS:67349183758
SN - 0143-4160
VL - 45
SP - 554
EP - 565
JO - Cell Calcium
JF - Cell Calcium
IS - 6
ER -