Phosphoinositide regulation of TRP channels

Tibor Rohacs

doi:10.1007/978-3-319-05161-1_18

Phosphoinositide regulation of TRP channels

Tibor Rohacs

Research output: Chapter in Book/Report/Conference proceeding › Chapter

91 Scopus citations

Abstract

Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and voltage. Besides their presumably similar general architecture, probably the only common factor regulating them is phosphoinositides. The regulation of TRP channels by phosphoinositides is complex. There are a large number of TRP channels where phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2 or PIP2] acts as a positive cofactor, similarly to many other ion channels. In several cases, however, PI(4,5)P2 inhibits TRP channel activity, sometimes even concurrently with the activating effect. This chapter will provide a comprehensive overview of the literature on regulation of TRP channels by membrane phosphoinositides.

Original language	English (US)
Title of host publication	Mammalian Transient Receptor Potential (TRP) Cation Channels
Subtitle of host publication	Volume II
Publisher	Springer New York LLC
Pages	1143-1176
Number of pages	34
ISBN (Print)	9783319051604
DOIs	https://doi.org/10.1007/978-3-319-05161-1_18
State	Published - 2014

Publication series

Name	Handbook of Experimental Pharmacology
Volume	223
ISSN (Print)	0171-2004
ISSN (Electronic)	1865-0325

All Science Journal Classification (ASJC) codes

Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)

Keywords

PIP2
Phosphoinositides
Phospholipase C
TRP channel
TRPV1

Access to Document

10.1007/978-3-319-05161-1_18

Cite this

@inbook{78becbf43b3c4490ad90d4449a9d42dc,

title = "Phosphoinositide regulation of TRP channels",

abstract = "Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and voltage. Besides their presumably similar general architecture, probably the only common factor regulating them is phosphoinositides. The regulation of TRP channels by phosphoinositides is complex. There are a large number of TRP channels where phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2 or PIP2] acts as a positive cofactor, similarly to many other ion channels. In several cases, however, PI(4,5)P2 inhibits TRP channel activity, sometimes even concurrently with the activating effect. This chapter will provide a comprehensive overview of the literature on regulation of TRP channels by membrane phosphoinositides.",

keywords = "PIP2, Phosphoinositides, Phospholipase C, TRP channel, TRPV1",

author = "Tibor Rohacs",

year = "2014",

doi = "10.1007/978-3-319-05161-1_18",

language = "English (US)",

isbn = "9783319051604",

series = "Handbook of Experimental Pharmacology",

publisher = "Springer New York LLC",

pages = "1143--1176",

booktitle = "Mammalian Transient Receptor Potential (TRP) Cation Channels",

}

TY - CHAP

T1 - Phosphoinositide regulation of TRP channels

AU - Rohacs, Tibor

PY - 2014

Y1 - 2014

N2 - Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and voltage. Besides their presumably similar general architecture, probably the only common factor regulating them is phosphoinositides. The regulation of TRP channels by phosphoinositides is complex. There are a large number of TRP channels where phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2 or PIP2] acts as a positive cofactor, similarly to many other ion channels. In several cases, however, PI(4,5)P2 inhibits TRP channel activity, sometimes even concurrently with the activating effect. This chapter will provide a comprehensive overview of the literature on regulation of TRP channels by membrane phosphoinositides.

AB - Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and voltage. Besides their presumably similar general architecture, probably the only common factor regulating them is phosphoinositides. The regulation of TRP channels by phosphoinositides is complex. There are a large number of TRP channels where phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2 or PIP2] acts as a positive cofactor, similarly to many other ion channels. In several cases, however, PI(4,5)P2 inhibits TRP channel activity, sometimes even concurrently with the activating effect. This chapter will provide a comprehensive overview of the literature on regulation of TRP channels by membrane phosphoinositides.

KW - PIP2

KW - Phosphoinositides

KW - Phospholipase C

KW - TRP channel

KW - TRPV1

UR - http://www.scopus.com/inward/record.url?scp=84958539229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958539229&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-05161-1_18

DO - 10.1007/978-3-319-05161-1_18

M3 - Chapter

C2 - 24961984

AN - SCOPUS:84958539229

SN - 9783319051604

T3 - Handbook of Experimental Pharmacology

SP - 1143

EP - 1176

BT - Mammalian Transient Receptor Potential (TRP) Cation Channels

PB - Springer New York LLC

ER -

Phosphoinositide regulation of TRP channels

Abstract

Publication series

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this