Phosphoinositide regulation of TRP channels

Research output: Chapter in Book/Report/Conference proceedingChapter

91 Scopus citations


Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and voltage. Besides their presumably similar general architecture, probably the only common factor regulating them is phosphoinositides. The regulation of TRP channels by phosphoinositides is complex. There are a large number of TRP channels where phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2 or PIP2] acts as a positive cofactor, similarly to many other ion channels. In several cases, however, PI(4,5)P2 inhibits TRP channel activity, sometimes even concurrently with the activating effect. This chapter will provide a comprehensive overview of the literature on regulation of TRP channels by membrane phosphoinositides.

Original languageEnglish (US)
Title of host publicationMammalian Transient Receptor Potential (TRP) Cation Channels
Subtitle of host publicationVolume II
PublisherSpringer New York LLC
Number of pages34
ISBN (Print)9783319051604
StatePublished - 2014

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)


  • PIP2
  • Phosphoinositides
  • Phospholipase C
  • TRP channel
  • TRPV1


Dive into the research topics of 'Phosphoinositide regulation of TRP channels'. Together they form a unique fingerprint.

Cite this