The organic solvent soluble portion of gastric secretion from patients with stomach disease constituted from 15 to 58% of dry weight, whereas secretion from healthy individuals contained on average about 25% of solvent soluble material. This increase in total lipids was due to an increase in neutral lipids (cholesterol, glycerides), glyceroglucolipids, and was associated with the presence of phospholipids and bile acids which were not detectable in the secretion of healthy individuals. Analyses of phospholipids showed variations in the amount and proportion of two major phospholipids, lysolecithin and lecithin. Up to 78.5% of phospholipids was found in the form of lysolecithin. This indicates a reflux of duodenal chyme into stomach, which would not only increase the concentration of the lipids directly but would also evoke a depletion of the native lipids (glyceroglucolipids) from in the gastric mucous barrier. This accords with increased levels of glyceroglucolipids found in pathological samples. Glyceroglucolipids, which comprise up to 50% of the gastric mucous barrier lipids may play important role in the defense mucosa against compounds such as lysolecithin and bile acids.
|Original language||English (US)|
|Number of pages||1|
|Journal||IRCS Medical Science|
|State||Published - Jan 1 1979|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)