Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1a knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1a knockout mice. These data suggest that skeletal muscle-PGC-1a is important for leucinemediated mTOR activation and protein biosynthesis.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
- Muscle specific PGC-1a knockout mouse