Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1a knockout mice

Ryoji Yoshimura, Kimiko Minami, Junichiro Matsuda, Naoki Sawada, Shinji Miura, Yasutomi Kamei

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1a knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1a knockout mice. These data suggest that skeletal muscle-PGC-1a is important for leucinemediated mTOR activation and protein biosynthesis.

Original languageEnglish (US)
Pages (from-to)288-290
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume80
Issue number2
DOIs
StatePublished - 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Keywords

  • 4EBP
  • Leucine
  • MTOR
  • Muscle specific PGC-1a knockout mouse

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