Phosphorylation of smads by intracellular kinases

Fang Liu, Isao Matsuura

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Smad proteins transduce the TGF-ß family signal at the cell surface into gene regulation in the nucleus. In addition to being phosphorylated by the TGF-ß family receptors, Smads are phosphorylated by a variety of intracellular kinases. The most studied are by cyclin-dependent kinases, the MAP kinase family members, and GSK-3. Phosphorylation by these kinases regulates Smad activities, leading to various biological effects. This chapter describes the methods for analyzing Smad phosphorylation by these kinases.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages93-109
Number of pages17
DOIs
StatePublished - Jan 1 2016

Publication series

NameMethods in Molecular Biology
Volume1344
ISSN (Print)1064-3745

Fingerprint

Phosphotransferases
Phosphorylation
Smad Proteins
Glycogen Synthase Kinase 3
Cyclin-Dependent Kinases
Mitogen-Activated Protein Kinase Kinases
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Keywords

  • CDKs
  • GSK-3
  • MAPKs
  • Phosphorylation
  • Smad

Cite this

Liu, F., & Matsuura, I. (2016). Phosphorylation of smads by intracellular kinases. In Methods in Molecular Biology (pp. 93-109). (Methods in Molecular Biology; Vol. 1344). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-2966-5_5
Liu, Fang ; Matsuura, Isao. / Phosphorylation of smads by intracellular kinases. Methods in Molecular Biology. Humana Press Inc., 2016. pp. 93-109 (Methods in Molecular Biology).
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Liu, F & Matsuura, I 2016, Phosphorylation of smads by intracellular kinases. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1344, Humana Press Inc., pp. 93-109. https://doi.org/10.1007/978-1-4939-2966-5_5

Phosphorylation of smads by intracellular kinases. / Liu, Fang; Matsuura, Isao.

Methods in Molecular Biology. Humana Press Inc., 2016. p. 93-109 (Methods in Molecular Biology; Vol. 1344).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Liu F, Matsuura I. Phosphorylation of smads by intracellular kinases. In Methods in Molecular Biology. Humana Press Inc. 2016. p. 93-109. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-2966-5_5