During meiosis homologous chromosomes normally pair, undergo reciprocal recombination, and then segregate from each other. Distributive disjunction is the meiotic segregation that is observed in the absence of homologous recombination and can occur for both nonrecombinant homologous chromosomes and completely nonhomologous chromosomes. While the mechanism of distributive disjunction is not known, several models have been presented that either involve or are completely independent of interactions between the segregating chromosomes. In this report, we demonstrate that distributive disjunction in Saccharomyces cerevisiae is preceded by an interaction between nonhomologous chromosomes.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Jan 4 1994|
All Science Journal Classification (ASJC) codes
- Saccharomyces cerevisiae
- chromosome pairing