Physical mapping of chromosomes using unique probes

Farid Alizadeh, Richard M. Karp, Deborah K. Weisser, Geoffrey Zweig

Research output: Chapter in Book/Report/Conference proceedingConference contribution

27 Scopus citations

Abstract

Described in this paper are several combinatorial algorithms for reconstructing a DNA strand given a collection of overlapping fragments of the strand. The goal of physical mapping is to infer how the clones overlap to form the DNA molecule, given the data about each clone. Focus of the note is on the Sequence Tagged Site (STS) mapping strategy which is widely used for physical mapping within the Human Genome project and other related molecular biology projects. Algorithms presented are used to determine probe ordering, given data for each clone indicating which probes hybridize to it.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual ACM SIAM Symposium on Discrete Algorithms
PublisherPubl by ACM
Pages489-500
Number of pages12
ISBN (Print)0898713293
StatePublished - 1994
Externally publishedYes
EventProceedings of the Fifth Annual SIAM Symposium on Discrete Algorithms - Arlington, VA, USA
Duration: Jan 23 1994Jan 25 1994

Publication series

NameProceedings of the Annual ACM SIAM Symposium on Discrete Algorithms

Other

OtherProceedings of the Fifth Annual SIAM Symposium on Discrete Algorithms
CityArlington, VA, USA
Period1/23/941/25/94

All Science Journal Classification (ASJC) codes

  • Software
  • General Mathematics

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