Physiologic effects of lowering caloric intake in nonhuman primates and nonobese humans

Susan B. Roberts, Xavier Pi-Sunyer, Lewis Kuller, Mark A. Lane, Peter Ellison, Jerilynn C. Prior, Susan Shapses

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Caloric restriction (CR) reduces the rate of aging and increases life span in all small animal species studied to date, but the effects of CR in humans remain uncertain. This review summarizes current knowledge of the effects of CR in nonhuman primates and humans. The results suggest that CR has a range of beneficial effects in nonhuman primates studied under laboratory conditions, and short-term markers of CR seen in animal models appear to occur in humans subject to CR also. However, the overall benefit of CR in human populations remains to be established, and studies in human populations are needed.

Original languageEnglish (US)
Pages (from-to)66-75
Number of pages10
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume56
Issue number1
StatePublished - Mar 2001

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

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